Your map is *really* huge! Some things I noticed:
Major line of sight issues occur in almost all of the rooms, the worst one can be seen on this image:
(screenshot 1)
The LOS between LG and GL is also inacceptable.
Item placement is also strange as you already noticed. You can get Quad, RG and BFG in <5 secs:
(screenshot 2)
Suggestions:
* make the rooms smaller
* split the loooooooong hallway (the one with the MH, screenshot 1) in smaller LOS-pieces by having the player run around things on the walls. see this image:
*change item placement. For TDM, create more than one interesting spot on the map, otherwise both teams will try to camp the current QUAD/RG/BFG location and the team that didn't get Quad will run and hide in the wastelands.
* if you want to keep the BFG move it to a place far away from quad, the RG should go to a third place as it is a very powerfull weapon, especially on a map of this scale
* add more vertical action
* add different height levels to the ground, at least add some small stairs the player has to walk up and down
* start with a smaller map if you're not that familiar with Radiant yet (don't know if that applies to you). A huge map means lots of work and can be disappointing to start with.