white ppl r mutants...

Post by **Freakaloin** » Sun Dec 18, 2005 5:40 pm

tis a fact...fuck u???...

http://www.washingtonpost.com/wp-dyn/co ... 28_pf.html

Post by **Survivor** » Sun Dec 18, 2005 5:54 pm

Interesting read for change.

Post by **werldhed** » Sun Dec 18, 2005 6:07 pm

Caused by a single base-substitution mutation? That's impressive. I'm skeptical, as usual.

Post by **Survivor** » Sun Dec 18, 2005 6:11 pm

it says 1/3 of the melanine production reduction was caused by that gene. Several others are responsible for the other 2/3.

Post by **tnf** » Sun Dec 18, 2005 6:32 pm

every fucking characterstic present in every fucking person originally started as a mutation.

Post by **Freakaloin** » Sun Dec 18, 2005 6:34 pm

fuck u...

Post by **tnf** » Sun Dec 18, 2005 6:34 pm

and werdheld, you can read teh whole Science paper here (all about zebrafish pigmentation...not quite the breakthrough the mainstream media touts it as):

http://www.sciencemag.org/cgi/content/f ... siteid=sci

"SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans"

"Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation."

Post by **tnf** » Sun Dec 18, 2005 6:35 pm

yes goof, even those things that make the 'help you girls' the way they are came from mutations.

Post by **Duhard** » Sun Dec 18, 2005 6:38 pm

Freakaloin wrote:fuck u...

someone ban this nerd..

Post by **tnf** » Sun Dec 18, 2005 6:39 pm

soon enough.

Post by **werldhed** » Sun Dec 18, 2005 6:42 pm

tnf wrote:and werdheld, you can read teh whole Science paper here (all about zebrafish pigmentation...not quite the breakthrough the mainstream media touts it as):

http://www.sciencemag.org/cgi/content/f ... siteid=sci

"SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans"

"Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation."

Cool. Thanks for the link... I'll give it a read after my headache goes away. :icon32: