Quake3World

tis a fact...fuck u???...

http://www.washingtonpost.com/wp-dyn/co ... 28_pf.html

Interesting read for change.

Caused by a single base-substitution mutation? That's impressive. I'm skeptical, as usual.

it says 1/3 of the melanine production reduction was caused by that gene. Several others are responsible for the other 2/3.

every fucking characterstic present in every fucking person originally started as a mutation.

fuck u...

and werdheld, you can read teh whole Science paper here (all about zebrafish pigmentation...not quite the breakthrough the mainstream media touts it as):

http://www.sciencemag.org/cgi/content/f ... siteid=sci

"SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans"

"Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation."

yes goof, even those things that make the 'help you girls' the way they are came from mutations.

Freakaloin wrote:fuck u...

someone ban this nerd..

soon enough.

tnf wrote:and werdheld, you can read teh whole Science paper here (all about zebrafish pigmentation...not quite the breakthrough the mainstream media touts it as):

http://www.sciencemag.org/cgi/content/f ... siteid=sci

"SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans"

"Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation."

Cool. Thanks for the link... I'll give it a read after my headache goes away. :icon32: