Quake3World

Saturn - Is the drug Naltrexone?
I'm finding lots of info on naloxone and naltrexone being used for rapid detox as well as combating opiate toxicity (form od'ing), but that still seems to leave the question - how can they act so fast if there is already opiate bonded to the receptor?

Is there a series of 'binding and unbiding' that takes place between opiate molecules and the different receptors for them in the brain? (i.e. can the same molecule be bound, released, then bound again to perpetuate the effect?) I've not heard of that type of receptor/ligand binding model before, but I'm getting myself more and more confused about something I should know the answer to...heh.

So, if that type of binding occurs, then I could see how these different receptor antagonists (naloxone, naltrexone, nalmefene) can block the opiates...

Hrmmm..

" Classic opioid toxicity, such as that seen with heroin, produces the clinical triad of miosis, respiratory depression, and CNS depression. The routes of exposure are varied and include oral, intravenous, insufflation, and transdermal. Patients with clonidine toxicity can present in a similar fashion, and the syndrome may be accompanied by bradycardia, hypotension, and periodic respiratory apnea.

Naloxone. Naloxone was the first pure opiate antagonist developed. It can be given intravenously, intramuscularly, sublingually, or via an endotracheal tube.

Administration will reverse almost all effects of the opioid, including respiratory and CNS depression, analgesia, miosis, and decreased peristalsis.43 The duration of action of naloxone is short (i.e., only 30-60 minutes). Since most opioid agents last longer than 30 minutes, a continuous infusion of naloxone is usually necessary. The initial dose of naloxone is 2-10 mg, regardless of age. Synthetic opiates will require more antidote. If a positive response is noted, a naloxone maintenance infusion of two-thirds the initial dose per hour should be started and titrated to effect.44 Patients should be monitored for at least 90 minutes prior to discharge from the ED. Longer-acting opioid antagonists are now available (e.g., nalmefene, naltrexone), but their role in the acute care setting needs to be defined. Naloxone can sometimes be effective in reversing clonidine toxicity. "

dmmh wrote:if you need coffee every thursday eve at 8 pm exactly, youre addicted.

Yeah, but that doesn't happen.

An addiction is different from a habit. I had the habit of drinking lots of diet coke several times in my life now. During those times, I needed the diet coke to stay awake.
But I could drop that habit simply by not doing it anymore. I quit drinking caffeinated beverages at all and I'm not missing it one bit.

And I have an addiction to cigarettes. I say have, because even though I haven't smoked a cigarette in 3 months, I still get pretty intense cravings.
It gets to the point where I start to think taking up smoking again might enhance my quality of life so much that it's worth the health risks.

See a difference? That's the difference between a habit and an addiction.

And all Doombrain and I were saying is that we believe your XTC 'addiction' was more of a habit than an addiction.

Hell, the only reason I jump so much on every "quit smoking" and "addiction" thread I see is that I hope someone will give me a good reason to start smoking again.

SplishSplash wrote:

dmmh wrote:if you need coffee every thursday eve at 8 pm exactly, youre addicted.

Yeah, but that doesn't happen.

An addiction is different from a habit. I had the habit of drinking lots of diet coke several times in my life now. During those times, I needed the diet coke to stay awake.
But I could drop that habit simply by not doing it anymore. I quit drinking caffeinated beverages at all and I'm not missing it one bit.

And I have an addiction to cigarettes. I say have, because even though I haven't smoked a cigarette in 3 months, I still get pretty intense cravings.
It gets to the point where I start to think taking up smoking again might enhance my quality of life so much that it's worth the health risks.

See a difference? That's the difference between a habit and an addiction.

And all Doombrain and I were saying is that we believe your XTC 'addiction' was more of a habit than an addiction.

dont want to spil it for you, but youve been addicted to the cola then. just because you dont have cravings anymore doesnt mean it isnt an addiction.

you were addicted to caffeine, physically I mean. you just gave us the proof. seeeeeeeeee

SplishSplash wrote:Hell, the only reason I jump so much on every "quit smoking" and "addiction" thread I see is that I hope someone will give me a good reason to start smoking again.

theres enough reasons, you just have to wanne see them

http://news.bbc.co.uk/1/hi/talking_point/3488809.stm

I don't know if it still can work after you have started smoking and also after a certain age, I mean young kids vs adults.
When I was at primary school, the teacher showed us pics of smokers’ lungs and brains, I found them so gross that it convinced me right away never to start smoking.

Graphic images of a human brain after a stroke due to smoking



Lung cancer


Pete

Yeah thanks for grossing everybody out pete.

And great decision you made there.

Bah, smokers who get cancer are the lucky ones. You should see people with emphysema.

I don't like how non-smokers try to impose their will of a non-smoking enviroment just the same as they don't like being in a smoking enviroment.

SplishSplash wrote:Hell, the only reason I jump so much on every "quit smoking" and "addiction" thread I see is that I hope someone will give me a good reason to start smoking again.

you want to stink like an ashtray no?

I've been addicted to weed for over 3 years now...to the point that I can't even fall asleep without smoking a joint.

But I mostly smoke during the evenings after a good day's work so that's prolly why I can't fall asleep without smoking some weed.

any questions?

How does that affect the lifting for you, or does it?

Does weed ever kill your motivation to train? I've heard some say that when they were really using it a lot they had a tough time making it to the gym, and if they did, they pretty much just went through the motions.

Synthol would be a better addiction. Or deca.

I tried some real speed last weekend for the first time in my life and wow...this shit is so fucking dangerous...good buzz but I almost lost 5 lbs because I couldn't sleep and eat for 2 days....

It's really sad to know the side effects of those pills...a girl I used to date destroyed her life with that shit...she lost 30 lbs and lost her job just because of those pills...she was soooo fucking hot when I met her

tnf wrote:How does that affect the lifting for you, or does it?

Does weed ever kill your motivation to train? I've heard some say that when they were really using it a lot they had a tough time making it to the gym, and if they did, they pretty much just went through the motions.

Synthol would be a better addiction. Or deca.

Well it never killed my motivation to lift but it certainly makes it tougher on my body sometimes...some ppl say that weed smoke is 3 times worse than cigarette smoke...is that true?!

Well anyways I never smoke before lifting but I have some friends who do it...dunno how they can...smoking weeed makes me feel lazy.

Duhard wrote:

tnf wrote:How does that affect the lifting for you, or does it?

Does weed ever kill your motivation to train? I've heard some say that when they were really using it a lot they had a tough time making it to the gym, and if they did, they pretty much just went through the motions.

Synthol would be a better addiction. Or deca.

Well it never killed my motivation to lift but it certainly makes it tougher on my body sometimes...some ppl say that weed smoke is 3 times worse than cigarette smoke...is that true?!

Well anyways I never smoke before lifting but I have some friends who do it...dunno how then can...smoking weeed makes me feel lazy.

Dunno about it being 3x worse than smokes (to be honest, you can't really quantify one thing as being 3x or 10x or whatever worse than another.) Weed smoke is certainly not 100% benign though...but I don't think it is any worse than cigarette smoke. I'm sure people on these forums will have more info.

I need to get back into the gym. Now I feel lazy.

Arnold smoked weed, though.

tnf wrote: I need to get back into the gym. Now I feel lazy.

Well you just have to think about the days when you used to train a lot and the feeling you had after a good workout and you'll be pumping iron in no time :P

the thing with mixing weed and activities is to do it just before you start or just after.

if you do nothing while you are stoned, you do get lazy.

imo anyways.